erythematous Lupus

Classically, the diseases autoinmunes of the skin are classified in two great groups, according to their cutaneous manifestations: processes vesículo-ampollosos /ej Penfigo) and nonvesicular (ej. Lupus).

THAT IT IS LUPUS:
Autoinmune is an inflammation. Circulating complexes form antigen-antibody causes of inflammatory injuries erythematous lupus is not a hereditary disease. It is not either of infectious nature, reason why it is acquired neither is transmitted by I infect, nor has nothing to do with the cancer, Which is the cause of erythematous lupus. Then What is what it causes it:
Our organism has defense mechanisms that they protect to him of which it is detrimental for him. The set of these mechanisms denominates immune system. Think about an infected wound: the organism has realized of which it is invaded by microbes. Then, it tries to make arrive more blood at that zone and, for it, the circulation dilates. In addition, the walls of the blood vessels of the region become more permeable and allow that they leave the blood cells, the leukocytes that are absolutely necessary for the defense of the organism and its paper is most important for the defensive reaction of the organism.
Of form similar to that we have described for the infections, the immune system is in charge to eliminate weaves injured and altered by a blow or a burn. Until now we have analyzed the normal immune answer (infections, blows, burns etc?)

We could summarize saying that the patient with erythematous lupus is ?allergic? to parts of his own organism. This situation, in which an individual reacts against its own organism, is what autoimmunity is called. Lupus is, therefore, a disease autoinmune.

It exists a clear Afghan racial predisposition, Beagle, Irish Setter, Collie, Bobtail, Caniche and Pastor Alemán affecting mainly to females and adult animals (average 6 years). Few cases in cats have been described. In veterinary medicine erythematous lupus is classified in:
* LED (discoide erythematous lupus)
* THEM (sistémico erythematous Lupus)
* SEUDOLUPUS (false lupus)

LED: It can affect skin and mucocutaneas unions in preference in the face and edges of the ears, the clinical signs but evident they are piodermias, seborrea, prurito and eritema with ulceraciones. An example of how a lupunica injury can be originated would be: at the outset they appear injuries as zones in the face without pigmentación (ej.nariz) soon that zone erodes, soon descama and a scab forms, often is secondary infection, bled constant and increase of the injury in the time, is of favorable prognosis with treatment inmunosupresivos: Sistémicos corticoids, quimioterápicas drugs (you would ej.leukeran) and/or high doses of oral Vit and.

THEM: The disease can be slight or burdens in the dogs and it is accompanied with affection of the skin, the joints, the kidneys, the lungs, the nervous system, the serosas, the alimentary canal and the apparatus cardiocirculatorio with or without alterations of hemograma (anemia, leucopenia), the following signs can appear individually or in combination. It is possibly, the paradigm of the diseases autoinmunes: the lúpicos patients develop without number of immunological alterations that severely jeopardize the life of the animal affected in the serious cases. The course is chronic and it does not have itself decisive but palliative treatment in the slight presentation.

SEUDOLUPUS: It is not true lupus and in ralidad we would not have to classify it here but it is important to consider that numerous drugs that induce practically identical a clinical and immunological picture to THEM. Pseudolupus is a reversible process after suppressing the medicine, the clinical manifestations consist, fundamentally, in general symptoms, pains you will articulate and collects of liquid in serosas membranes.

Bibliography

Author: MV Adelaida A. Goldman

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